Drug for preventing breast cancer

Anastrozole is an aromatase inhibitor that works by lowering estrogen levels in the body. Since many breast cancers are estrogen receptor-positive (ER+), reducing estrogen helps prevent the growth of these cancer cells.

In the context of breast cancer prevention, especially in postmenopausal women at high risk, anastrozole has been shown to significantly reduce the likelihood of developing breast cancer. Key effects include:

• Reduction in risk: Clinical trials, like the IBIS-II, show a 53% reduction in the risk of developing breast cancer in women taking anastrozole compared to those on a placebo.

• Targeting hormone-sensitive cancers: It is most effective against hormone receptor-positive breast cancers (ER+).

• Long-term impact: The protective effect continues for years after the treatment is stopped.

Side effects of anastrozole include bone density loss, joint pain, and hot flashes, but these are considered manageable in most cases.

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